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Laboratory analysis at PentaBase
1-step HRM Analysis

MicroSight® MSI

Patients with microsatellite instable tumors benefit from specific treatments more than others. Therefore, early detection of instability becomes important. MicroSight MSI allows for such a result in less than two hours and provides a precise, personalised and, most importantly, beneficial treatment plan

Specifications How to order
Intended use of MicroSight® MSI 1-step HRM analysis

World Cancer Research Fund’s data (2020) showed that 10.7% (3'rd most occurring) of all new global cancers diagnosed were colorectal cancer. PentaBase’s MicroSight MSI is a critical analysis of microsatellite instability commonly found, among others, within colorectal cancer patients.
The MicroSight MSI assay is a highly sensitive analysis of human DNA samples that gives insight into the instability within five different biomarkers (mononucleotide microsatellite loci). This makes it a careful and precise stratification tool to assist with treatment planning. The analysis is based on validated methods, withholds flexibility through paired or universal references (UR), is incredibly cost-efficient due to the minimal hands-on time needed, and is created to sincerely strive for optimal caring of its end-users.  

Advantages of MicroSight® MSI: 

Results in less than two hours

Low risk of cross contamination

Objective analysis – No biased data interpretation

One instrument analysis – minimal hands-on time

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WE MAKE OURSELVES ACCOUNTABLE

One of the fastest MSI Analysis in the world

We deliver the best possible solutions for patients’ health situations. Consequently, MicroSight MSI assists in making the proper treatment plan, the first time around. Therefore, it provides results in less than two hours, flexibility through two versions, precise analysis of up to seven patients simultaneously and does so all in one instrument. 

Other Assays

2

Hour result time

7

Patients

2

Versions

1

Instrument

Flexible Use for diagnostics

Paired Samples
MicroSight MSI offers an adaptive analysis of either paired or unpaired samples. A biopsy from a tumor and cell-free DNA from the patient are placed into two sets of 5-well PCR strips in the paired samples analysis. The strips are analyzed on our efficient real-time PCR machine, BaseTyper™ 48, where each run allows for quick analysis of 4 different patients simultaneously (4 sets of 5-well strips).

  • The unique analysis of each patient’s specific DNA constitution.
  • Needs only < 1 positive microsatellite
  • A quick, simultaneous 4-patient analysis

Instructions of Use:

Paired Tumor Samples
Flexible Use for diagnostics

Unpaired Samples
The unpaired samples analysis only needs tumor DNA from the patient, which is then compared to a universal reference. The tumor DNA is placed into 5-well strips, but because of the universal reference that only needs one 5-well strip, each run allows for quick analysis of seven different patients simultaneously (7x5-well strips + 1 UR 5-well strip). 

  • High throughput because of universal reference
  • Needs a minimum of 3 positive microsatellites 
  • A quick, simultaneous 7-patient analysis

Instructions of Use:

Unpaired Tumor Samples
Covid-19 pcr analysis handling


Product Information

Please refer to the IFU for acceptable sample type and collection device combinations.
Formats
Paired & Unpaired (Universal Reference) 
Loci
BAT25, BAT26, NR22, NR24 & MONO27
No. of Reactions
Box of 16 reactions 
Configuration
Ready-to-use assays in 5-well PCR strip 
Shipment Condition
≤-20°C or on Dry ice
Storage
Range between -20°C and -80°C
Instrumentation Required
Nucleic Acid Extraction System & BaseTyper™ Real-Time PCR instrument
Result Time
Less than 2 hours
Concentration of Genomic DNA
1-10 ng/µL for real-time PCR
Reagents and Materials
Pre-aliquoted 0.2 mL PCR strips
Validated Extraction methods
QIAamp DNA FFPE Tissue Kit, BaseRelease™ FFPE & BasePurifier™ FFPE
Intended use
CE IVD
Approved Instrument for Use of MicroSight® MSI 1-step HRM analysis

PentaBase systems for analysis

The MicroSight® MSI 1-step HRM analysis is designed and validated for usage on BaseTyper™48.4 (PentaBase PCR instrument).

Fast and accurate real-time PCR

Minimal hands-on time required

Small, compact instrument with mobile capabilities

BaseTyper™ 48
BaseTyper PCR equipment
Distributor celloxa Distributor Anachem Greec/Cyprus Distributor Dynex Distributor AmpliTech Distributor Ridacom Distributor Resnova
Sponsor and collaborator
How to order

Order MicroSight® MSI 1-step HRM analysis

Are you interested in our assays for analysing the stability/instability of five mono-nucleotide microsatellite loci? Find a local distributor, become our distributor or order your assay at PentaBase directly.

Order with PentaBase Order from your local distributor Become distributor
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