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Laboratory analysis at PentaBase




Assay | CANCER DIAGNOSTICS

SensiScreen®

Combining simplex and multiplexing capabilities with PentaBase’s unique DNA technologies and open platform designs, SensiScreen® assays deliver profound sensitivity and flexibility in the analysis of somatic mutations, to aid in the selection of proper cancer treatment based on the patient’s mutational status

Specifications Details
INTRODUCTION TO SENSISCREEN®

Common cancers including colorectal cancer, lung cancer and malignant melanoma are characterized by the accumulation of somatic mutations, some of which  are known to affect a patient’s response to cancer treatments. SensiScreen® qPCR-based assays provide fast and reliable somatic mutation detection to support rapid initiation of the optimal cancer treatment.

The assay is available in 2 formats: 

Analysis of liquid biopsies

Analysis of FFPE biopsies

Introduction to SensiScreen® Liquid

SensiScreen® liquid provides a highly effective analysis of somatic mutations done on top-of-the-line real-time PCR equipment such as the BaseTyper™ 48. The high sensitivity of SensiScreen® liquid allows the detection of down to one copy of genomic human DNA in liquid biopsies. In addition to its use as an aid in treatment selection, SensiScreen® liquid is highly suitable for monitoring a patient’s response progression and resistance to cancer therapies using liquid biopsies. Thereby, it allows for a more personalised treatment planning and adjustment. SensiScreen® liquid assay can be provided as either Ready-to-use (RTU) or Dispense-ready (DR) versions to offer optimal convenience for its users.

SensiScreen® Liquid benefits:

Result in less than three hours

Limit of detection down to one copy

Simplex or multiplex configurations.

High sensitivity and cost-effective

Publication
introduction to SENSISCREEN® FFPE

SensiScreen® FFPE provides an astoundingly efficient and sensitive analysis of somatic mutations found in solid biopsies. The analysis is done on top-of-the-line real-time PCR equipment such as the BaseTyper™ 48.4. This enables the assay to detect down to 0.25 per cent of mutated DNA in a wild type background in solid biopsies. SensiScreen® FFPE assay can be provided as either Ready-to-use (RTU) or Dispense-ready (DR) versions to offer optimal convenience for its users.

SensiScreen® FFPE benefits:

Result in less than three hours

Limit of detection down to point 0.25 per cent of mutated DNA

High sensitivity and cost-effective

Simplex or multiplex configurations

Publication
Put your health first

We proudly provide the answers

We deliver the best possible solutions for patients’ health situations. Therefore, SensiScreen® is an assay that considers optimal patient care a must and convenience and precision a priority for its users.
As a result, it offers two formats (Liquid and FFPE), two versions (RTU and DR), and two configurations (Simplex and Multiplex) all in one single solution: SensiScreen®.

Other Assays Order Now

2

Formats

2

Versions

2

Configurations

1

Solution

Product information

Please refer to the IFU for acceptable sample type and collection device combinations.
Format
Ready-To-Use and Dispense-Ready
Reagents and materials
DNA oligomers modified with fluorophores, quenchers and proprietary PentaBases
Configuration
Simplex and multiplex
Detection Sensitivity
0.25-1 % mutation in a 50 ng wild type backround
Design
Reference assay and mutation assay
Shipment
With dry ice or -80°C ice packs
Storage
Range between -20°C and -80°C
Content / No. of Reactions
Ready-to-use: 12 or 60
Dispense ready: 20 or 50
Result times
Less than 3 thours
Equipment Required
Template DNA (eg. extracted cell-free DNA (cfDNA) from liquid biopsies)
Real-Time PCR instrument
Targeting
V-raf BRAF EGFR KIT KRAS NRAS PIK3CA
FFPE: Intended use
CE IVD
Liquid: Intended use
For Research Use Only. Not for use in diagnostic procedures.
APPROVED INSTRUMENTS FOR USE OF SENSISCREEN® ASSAYS

The SensiScreen® assay is validated to be used on BaseTyper™48 (PentaBase PCR instrument) and the following instruments:

Rotor-Gene (Qiagen)

MX3000P/3005P (Agilent)

LightCycler® 96 + 480 (Roche)

CFX96TM (Bio-Rad)

ABI 7500/7900HT (Applied Biosystems)

MIC (Bio Molecular Systems)

MyGo Pro (IT-IS Life Science)

BaseTyper™48
Distributor celloxa Distributor Anachem Greec/Cyprus Distributor Dynex Distributor AmpliTech Distributor Ridacom Distributor Resnova
Sponsor and collaborator
How to order

SensiScreen®

Are you interested in our assays for stratification and monitoring? Find a local distributor, become our distributor or order your assay at PentaBase directly.

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